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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described by their focus on practical aspects of study design that include recruitment and consent, adherence and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from various geographical areas. This type of heterogeneity that is crucial for a pragmatic trial to be reliable and reduce bias in results is also essential. Too much heterogeneity, however could cause issues with the design of the trial.

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The goal of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are usually ordered by policymakers and practitioners to guide their decisions. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. However, 프라그마틱 정품인증 이미지 (Seo-Promosite.Ru) they shouldn't be used as a substitute for explanatory trials.

The pragmatism concept is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the features of a practical trial that include the recruitment process, the design and delivery of the intervention, and the follow-up.

There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.